circRNA basic information
circBase ID: hsa_circ_0001103
Name: -
Synonym: circ_0001103
Host Gene: hsa-miR-375
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: Osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: chondrocytes
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: SIRT1
Associated microRNA: hsa-miR-375
Biological function: Overexpression of circ_0001103 attenuated IL-1beta-induced chondrocyte apoptosis, inflammatory responses and ECM degradation.
Molecular mechanism: MiR-375 was targeted by circ_0001103, and miR-375 could bind to SIRT1. Circ_0001103 overexpression increased the expression of SIRT1 by suppressing miR-375.
Survival: -
Supported No.:
 1
Description:

Circ_0001103 governed the miR-375/SIRT1 axis to ameliorate IL-1beta-induced chondrocyte injuries, implying that circ_0001103 was a promising biomarker in OA pathogenesis.
Other information
Title:

Circ_0001103 alleviates IL-1beta-induced chondrocyte cell injuries by upregulating SIRT1 via targeting miR-375.

Journal: Clin Immunol
Published: 2021/4/6
PubMed ID: 33819576