circRNA basic information
circBase ID: -
Name: hsa_circ_SAMD4A
Synonym: -
Host Gene: hsa-miR-218-5p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HOS, U2OS
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KLF8
Associated microRNA: hsa-miR-218-5p
Biological function: knockdown of circSAMD4A or KLF8 sensitized osteosarcoma cells to DXR by mediating resistant cell viability, migration and invasion inhibition, and cell cycle arrest in vitro
Molecular mechanism: via regulating hsa-miR-218-5p and KLF8
Survival: -
Supported No.:
 2
Description:

circSAMD4A enhanced cell DXR resistance in osteosarcoma by regulating the miR-218-5p/KLF8 axis, suggesting a novel therapeutic target for therapy-resistant osteosarcoma.
Other information
Title:

CircSAMD4A contributes to cell doxorubicin resistance in osteosarcoma by regulating the miR-218-5p/KLF8 axis.

Journal: Open Life Sci
Published: 2021/4/6
PubMed ID: 33817271