circRNA basic information
circBase ID: -
Name: hsa_circ_KLHL24
Synonym: -
Host Gene: hsa-miR-1204
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: BT549, MDA-231, HCC38, SUM-159, MDA-453
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ALX4
Associated microRNA: hsa-miR-1204
Biological function: circKLHL24 overexpression blocked cell viability, colony formation, migration/invasion, and glycolysis progression.
Molecular mechanism: competitively targeted hsa-miR-1204, and hsa-miR-1204 reintroduction reversed the effects of circKLHL24 restoration
Survival: -
Supported No.:
 1
Description:

circKLHL24 blocked the progression of breast cancer by activating ALX4 through targeting miR-1204, which might be a novel perspective to understand the pathogenesis of breast cancer.
Other information
Title:

circKLHL24 Blocks Breast Cancer Development by Regulating the miR-1204/ALX4 Network.

Journal: Cancer Biother Radiopharm
Published: 2021/3/31
PubMed ID: 33781094