circRNA basic information
circBase ID: -
Name: hsa_circ_PPP1CC
Synonym: -
Host Gene: hsa-miR-103a-3p, hsa-miR-107
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HUVECs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGB1/TLR9/AIM2 pathway
Associated microRNA: hsa-miR-103a-3p, hsa-miR-107
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

Knockdown of circRNA PPP1CC relieved Pg-LPS-induced pyroptosis of VSMCs. Pyroptosis of VSMCs appears to promote atherosclerosis and may represent a novel therapeutic target for its treatment.
Other information
Title:

Circular RNA PPP1CC promotes Porphyromonas gingivalis-lipopolysaccharide-induced pyroptosis of vascular smooth muscle cells by activating the HMGB1/TLR9/AIM2 pathway.

Journal: J Int Med Res
Published: 2021/3/27
PubMed ID: 33769113