circRNA basic information
circBase ID: hsa_circ_0001666
Name: hsa_circ_FAM120B
Synonym: -
Host Gene: hsa-miR-330-5p, hsa-miR-193a-5p, hsa-miR-326
 
 
 
Disease basic information
DO ID:
 3969
DO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: TPC-1, IHH-4 , GLAG-66
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: ETV4
Associated microRNA: hsa-miR-330-5p, hsa-miR-193a-5p, hsa-miR-326
Biological function: Knocking down hsa_circ_0001666 expression inhibited cell proliferation, as evidenced by decreased cell viability, arrest of cell cycle progression at the G(1) phase and an increase in cell cycle_associated proteins
Molecular mechanism: via the miR_330_5p/miR_193a_5p/miR_326/ETV4 pathway
Survival: poor
Supported No.:
 1
Description:

hsa_circ_0001666 may function as an oncogene, promoting PTC tumorigenesis via the miR_330_5p/miR_193a_5p/miR_326/ETV4 pathway. This provides a basis for identifying potential novel therapeutic targets for PTC.
Other information
Title:

Circular RNA hsa_circ_0001666 sponges miR_330_5p, miR_193a_5p and miR_326, and promotes papillary thyroid carcinoma progression via upregulation of ETV4.

Journal: Oncol Rep
Published: 2021/3/25
PubMed ID: 33760216