circRNA basic information
circBase ID: -
Name: hsa_circ_PLXNB2
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9119
DO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: THP1, MV4;11, OCI-AML3, HL-60
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PLXNB2
Associated microRNA: -
Biological function: promoted cell proliferation and migration and inhibited apoptosis
Molecular mechanism: increased the expression of PLXNB2, BCL2 and cyclin D1, and reduced the expression of BAX
Survival: poor
Supported No.:
 2
Description:

we validated the high expression of circPLXNB2 and PLXNB2 in patients with AML. Elevated circPLXNB2 levels were associated with poor clinical outcomes in patients with AML. Importantly, circPLXNB2 accelerated tumour growth and progression, possibly by regulating PLXNB2 expression. Our study highlights the potential of circPLXNB2 as a new prognostic predictor and therapeutic target for AML in the future.
Other information
Title:

A circular RNA derived from PLXNB2 as a valuable predictor of the prognosis of patients with acute myeloid leukaemia.

Journal: J Transl Med
Published: 2021/3/25
PubMed ID: 33757550