circRNA basic information
circBase ID: hsa_circ_0023028
Name: -
Synonym: Circ_0023028
Host Gene: hsa-miR-486-3p
 
 
 
Disease basic information
DO ID:
 2876
DO name: laryngeal squamous cell carcinoma
Disease details: laryngeal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Tu686, AMC-HN-8
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: LASP1
Associated microRNA: hsa-miR-486-3p
Biological function: Circ_0023028 silencing suppressed LSCC cell proliferation, metastasis and cell cycle process and induced apoptosis in vitro and hampered tumor growth in vivo
Molecular mechanism: circ_0023028 could sponge hsa-miR-486-3p to regulate LASP1 expression in LSCC cells
Survival: -
Supported No.:
 1
Description:

Circ_0023028 knockdown might impede the progression of LSCC by regulating miR-486-3p/LASP1 axis, which could provide a novel insight on the mechanism of LSCC progression.
Other information
Title:

Circ_0023028 contributes to the progression of laryngeal squamous cell carcinoma by upregulating LASP1 through miR-486-3p.

Journal: Mol Cell Biochem
Published: 2021/3/24
PubMed ID: 33755879