circRNA basic information
circBase ID: hsa_circ_0006892
Name: -
Synonym: circ_0006892
Host Gene: hsa-miR-24
 
 
 
Disease basic information
DO ID:
 3083
DO name: chronic obstructive pulmonary disease
Disease details: chronic obstructive pulmonary disease
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PHLPP2
Associated microRNA: hsa-miR-24
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

PHLPP2 was targeted via miR-24, and miR-24 knockdown mitigated CSE-induced viability reduction and promotion of apoptosis and inflammatory response via regulating PHLPP2. Circ_0006892 could promote PHLPP2 expression via regulating miR-24. Circ_0006892 attenuated CSE-induced bronchial epithelial cell apoptosis and inflammatory response via regulating miR-24/PHLPP2 axis.
Other information
Title:

CircRNA circ_0006892 regulates miR-24/PHLPP2 axis to mitigate cigarette smoke extract-induced bronchial epithelial cell injury.

Journal: Biotechnol Appl Biochem
Published: 2021/3/19
PubMed ID: 33734482