circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF609
Synonym: -
Host Gene: hsa-miR-197-3p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HeLa, SiHa, HT-3, C-33A, Ca-Ski
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: E2F6
Associated microRNA: hsa-miR-197-3p
Biological function: circ-ZNF609 deletion repressed cell viability, migration and invasion in CC
Molecular mechanism: circ-ZNF609 upregulated E2F6 by interacting with hsa-miR-197-3p
Survival: -
Supported No.:
 1
Description:

circ-ZNF609 promoted CC progression through modulating the miR-197-3p/E2F6 axis as an oncogene. This finding offers a unique insight into CC molecular mechanism and suggests a potential target for CC therapy.
Other information
Title:

Circular RNA ZNF609 functions as a competing endogenous RNA in regulating E2F transcription factor 6 through competitively binding to microRNA-197-3p to promote the progression of cervical cancer progression.

Journal: Bioengineered
Published: 2021/3/19
PubMed ID: 33734009