circRNA basic information
circBase ID: -
Name: hsa_circ_PRKCI
Synonym: -
Host Gene: hsa-miR-335
 
 
 
Disease basic information
DO ID:
 3969
DO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: PTC-1 , IHH-4, SNU-790
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: E2F3
Associated microRNA: hsa-miR-335
Biological function: circ-PRKCI knockdown could suppress cell cycle progression of PTC cells and restrain the abilities of cell proliferation, colony formation, wound closure, invasion, glucose consumption and lactate production
Molecular mechanism: circ-PRKCI functioned as a sponge for hsa-miR-335 and hsa-miR-335 could further targeted E2F transcription factor-3 (E2F3),
Survival: poor
Supported No.:
 1
Description:

circ-PRKCI exerted oncogenic role in PTC by antagonizing cell progression and glycolysis via regulating miR-335/E2F3 axis, suggesting circ-PRKCI was a potential biomarker and target for PTC.
Other information
Title:

Silencing circRNA protein kinase C iota (circ-PRKCI) suppresses cell progression and glycolysis of human papillary thyroid cancer through circ-PRKCI/miR-335/E2F3 ceRNA axis.

Journal: Endocr J
Published: 2021/3/16
PubMed ID: 33716239