circRNA basic information
circBase ID: -
Name: hsa_circ_PDCD4
Synonym: circPDCD4
Host Gene: hsa-miR-21
 
 
 
Disease basic information
DO ID:
 0050117
DO name: disease by infectious agent
Disease details: postweaning multisystemic wasting syndrome
Species: human
Species details: human
Sample type: cell line
Sample type details: porcine kidney 15 (PK-15) cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PDCD4
Associated microRNA: hsa-miR-21
Biological function: we found that miR-21 overexpression induced the NF-¦ĘB pathway along with inflammation in cells exposed to PCV2.
Molecular mechanism: The results of RNA immunoprecipitation and dual-luciferase reporter (DLR) assay revealed that circPDCD4 acted as a miR-21 sponge and PDCD4 was a miR-21 target.
Survival: -
Supported No.:
 1
Description:

Thus, PCV2 activated the NF-¦ĘB pathway and cellular inflammatory responses through regulating circPDCD4, miR-21, and PDCD4 in PK-15 cells.
Other information
Title:

Porcine circovirus type 2 infection activates NF-kappaB pathway and cellular inflammatory responses through circPDCD4/miR-21/PDCD4 axis in porcine kidney 15 cell.

Journal: Virus Res
Published: 2021/3/14
PubMed ID: 33713752