circRNA basic information
circBase ID: -
Name: hsa_circ_TRAPPC6B
Synonym: -
Host Gene: hsa-miR-874-3p
 
 
 
Disease basic information
DO ID:
 399
DO name: tuberculosis
Disease details: tuberculosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: THP_1
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: ATG16L1
Associated microRNA: hsa-miR-874-3p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 2
Description:

circTRAPPC6B antagonises the ability of miR-874-3p to suppress ATG16L1 expression and activate and enhance autophagy sequestration to restrict Mtb growth in macrophages.
Other information
Title:

Circular RNA TRAPPC6B inhibits intracellular Mycobacterium tuberculosis growth while inducing autophagy in macrophages by targeting microRNA-874-3p.

Journal: Clin Transl Immunology
Published: 2021/3/13
PubMed ID: 33708385