circRNA basic information
circBase ID: hsa_circ_0000094
Name: -
Synonym: circRNA_0000094
Host Gene: hsa-miR-223-3p
 
 
 
Disease basic information
DO ID:
 5603
DO name: T-cell acute lymphoblastic leukemia
Disease details: T-cell acute lymphoblastic leukemia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Jurkat, CCRF-CEM, TALL-1, KOPTK1, HPB-ALL
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FBW7
Associated microRNA: hsa-miR-223-3p
Biological function: circ_0000094 overexpression remarkably suppressed T-ALL cell proliferation, migration, and invasion, and enhanced apoptosis while knocking down circ_0000094 enhanced the malignant phenotypes of T-ALL cells
Molecular mechanism: up-regulate the expression of FBW7 via repressing hsa-miR-223-3p expression
Survival: -
Supported No.:
 1
Description:

circ_0000094 impedes T-ALL progression by modulating the miR-223-3p/FBW7 axis.
Other information
Title:

Circular RNA circRNA_0000094 sponges microRNA-223-3p and up-regulate F-box and WD repeat domain containing 7 to restrain T cell acute lymphoblastic leukemia progression.

Journal: Hum Cell
Published: 2021/3/8
PubMed ID: 33677796