circRNA basic information
circBase ID: -
Name: hsa_circ_SLC39A8
Synonym: circ_SLC39A8
Host Gene: hsa-miR-591
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: chondrocytes
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IRAK3
Associated microRNA: hsa-miR-591
Biological function: Knockdown of circ_SLC39A8 inhibited apoptosis and inflammation in OA chondrocytes, while these effects were reversed by downregulating miR-591.
Molecular mechanism: Promotion cell viability effects of miR-591 were partially reversed by IRAK3 overexpression.
Survival: -
Supported No.:
 1
Description:

Our findings indicated that knockdown of circ_SLC39A8 delayed the progression of OA via modulating the miR-591-IRAK3 axis, providing new insight into the molecular mechanisms of OA pathogenesis.
Other information
Title:

Knockdown of Circ_SLC39A8 protects against the progression of osteoarthritis by regulating miR-591/IRAK3 axis.

Journal: J Orthop Surg Res
Published: 2021/3/5
PubMed ID: 33658057