circRNA basic information
circBase ID: -
Name: hsa_circ_CLK3
Synonym: -
Host Gene: hsa-miR-455-5p
 
 
 
Disease basic information
DO ID:
 50865
DO name: tongue squamous cell carcinoma
Disease details: tongue squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: CAL27, SCC15, SCC4
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PARVA
Associated microRNA: hsa-miR-455-5p
Biological function: CircCLK3 knockdown suppressed cell proliferation, migration invasion, and induced cell cycle arrest at G0/G1 phase in TSCC
Molecular mechanism: circCLK3 acted as a molecular sponge for hsa-miR-455-5p. PARVA was the target gene of hsa-miR-455-5p
Survival: -
Supported No.:
 1
Description:

circCLK3 exerts its carcinogenic effects on TSCC progression via absorbing miR-455-5p to upregulate PARVA, which expands our knowledge on the underlying mechanism of TSCC.
Other information
Title:

Circular RNA circCLK3 promotes the progression of tongue squamous cell carcinoma via miR-455-5p/PARVA axis.

Journal: Biotechnol Appl Biochem
Published: 2021/3/4
PubMed ID: 33655541