circRNA basic information
circBase ID: -
Name: hsa_circ_BRAF
Synonym: -
Host Gene: hsa-miR-1290
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: U251, T98G
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FBXW7
Associated microRNA: hsa-miR-1290
Biological function: Upregulation of circBRAF inhibited glioma cell proliferation and metastasis in vitro
Molecular mechanism: circBRAF elevated FBXW7 expression by targeting hsa-miR-1290
Survival: -
Supported No.:
 1
Description:

circBRAF elevated FBXW7 expression by targeting miR-1290. Introduction of miR-1290 or FBXW7 knockdown could counteract the inhibitory effects of circBRAF upregulation on the malignant phenotypes of glioma cells. Overexpression of circBRAF repressed the tumor growth in vivo. Upregulation of circBRAF suppressed glioma evolvement in vitro and in vivo by regulating miR-1290/FBXW7 axis, broadening the cognition of glioma progression.
Other information
Title:

Gain of circBRAF Represses Glioma Progression by Regulating miR-1290/FBXW7 Axis.

Journal: Neurochem Res
Published: 2021/3/3
PubMed ID: 33650075