circRNA basic information
circBase ID: -
Name: hsa_circ_WAC
Synonym: -
Host Gene: hsa-miR-142
 
 
 
Disease basic information
DO ID:
 60081
DO name: triple-receptor negative breast cancer
Disease details: triple-negative breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: MDA-MB-231, MDA-MB-468, HCC-1937, MDA-MB-361, MCF-7, MCF-10A
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: WWP1 and activating the PI3K/AKT pathway
Associated microRNA: hsa-miR-142
Biological function: -
Molecular mechanism: acted as a hsa-miR-142 sponge to relieve the repressive effect of hsa-miR-142 on its target WWP1
Survival: better
Supported No.:
 1
Description:

CircWAC/miR-142/WWP1 form a competing endogenous RNA (ceRNA) network to regulate PI3K/AKT signaling activity in TNBC cells and affect the chemosensitivity of cells.
Other information
Title:

CircWAC induces chemotherapeutic resistance in triple-negative breast cancer by targeting miR-142, upregulating WWP1 and activating the PI3K/AKT pathway.

Journal: Mol Cancer
Published: 2021/3/3
PubMed ID: 33648498