circRNA basic information
circBase ID: -
Name: hsa_circ_VMA21
Synonym: circVMA21
Host Gene: hsa-miR-199a-5p
 
 
 
Disease basic information
DO ID:
 0040085
DO name: bacterial sepsis
Disease details: Sepsis
Species: human
Species details: human
Sample type: cell line
Sample type details: THP-1 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: NRP1
Associated microRNA: hsa-miR-199a-5p
Biological function: circVMA21 overexpression could repress LPS-mediated cell viability, apoptosis, inflammation, and oxidative stress in THP-1 cells.
Molecular mechanism: The mechanical analysis suggested that circVMA21 regulated NRP1 expression through sponging miR-199a-5p.
Survival: -
Supported No.:
 2
Description:

CircVMA21 upregulation could attenuate LPS-triggered THP-1 cell injury through modulating the miR-199a-5p/NRP1 axis, hinting an underlying therapeutic strategy for sepsis patients.
Other information
Title:

Circular RNA circVMA21 ameliorates lipopolysaccharide (LPS)-induced acute kidney injury by targeting the miR-199a-5p/NRP1 axis in sepsis.

Journal: Biochem Biophys Res Commun
Published: 2021/3/2
PubMed ID: 33647793