circRNA basic information
circBase ID: -
Name: hsa_circ_FoxO1
Synonym: circRNA-FoxO1
Host Gene: hsa-miR-145
 
 
 
Disease basic information
DO ID:
 11830
DO name: myopia
Disease details: myopia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: RF/6A
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: VEGFA or ANGPT2
Associated microRNA: hsa-miR-145
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

circFoxO1 acted as the sponge of miR-145 to sequester and inhibit miR-145 activity, thereby inducing VEGFA or ANGPT2 expression. miR-145 could mimic the effects of circFoxO1 silencing on choroidal endothelial phenotypes.

Other information
Title:

Targeting choroidal vascular dysfunction via inhibition of circRNA-FoxO1 for prevention and management of myopic pathology.

Journal: Mol Ther
Published: 2021/3/2
PubMed ID: 33647458