circRNA basic information
circBase ID: -
Name: hsa_circ_PDE5A
Synonym: -
Host Gene: hsa-miR-362-5p
 
 
 
Disease basic information
DO ID:
 769
DO name: neuroblastoma
Disease details: neuroblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: SK-N-SH , SK-N-AS
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NOL4L
Associated microRNA: hsa-miR-362-5p
Biological function: The silencing of circPDE5A suppressed NB cell proliferation, migration, invasion, and glycolysis in vitro and diminished tumour growth in vivo.
Molecular mechanism: directly targeted hsa-miR-362-5p by binding to hsa-miR-362-5p
Survival: -
Supported No.:
 1
Description:

the knockdown of circPDE5A suppressed NB malignant progression at least in part by the regulation of the miR-362-5p/NOL4L axis, providing a novel rationale for developing circPDE5A as a potential target for NB management.
Other information
Title:

Silencing of circular RNA circPDE5A suppresses neuroblastoma progression by targeting the miR-362-5p/NOL4L axis.

Journal: Int J Neurosci
Published: 2021/2/27
PubMed ID: 33635749