circRNA basic information
circBase ID: -
Name: hsa_circ_DNM3OS
Synonym: -
Host Gene: hsa-miR-145-5p
 
 
 
Disease basic information
DO ID:
 4947
DO name: cholangiocarcinoma
Disease details: cholangiocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HuCCT1, HuH28
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MORC2
Associated microRNA: hsa-miR-145-5p
Biological function: Inhibition of circDNM3OS reduced xenograft tumor growth in vivo and constrained proliferation, colony formation, migration, invasion, induced apoptosis, and reduced glutamine metabolism of CCA cells in vitro
Molecular mechanism: CircDNM3OS sponged hsa-miR-145-5p to elevate MORC2 expression.
Survival: -
Supported No.:
 2
Description:

CircDNM3OS facilitates CCA growth and glutamine metabolism by regulating the miR-145-5p/MORC2 pathway, offering a novel mechanism to understand the progression of CCA.
Other information
Title:

Circular RNA circDNM3OS Functions as a miR-145-5p Sponge to Accelerate Cholangiocarcinoma Growth and Glutamine Metabolism by Upregulating MORC2.

Journal: Onco Targets Ther
Published: 2021/2/26
PubMed ID: 33628035