circRNA basic information
circBase ID: hsa_circ_0003489
Name: hsa_circ_CDK8
Synonym: -
Host Gene: hsa-miR-874-3p
 
 
 
Disease basic information
DO ID:
 9538
DO name: multiple myeloma
Disease details: multiple myeloma
Species: human
Species details: human
Sample type: cell line
Sample type details: MM1.R
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: HDAC1
Associated microRNA: hsa-miR-874-3p
Biological function: Knocking down hsa_circ_0003489 significantly inhibited the viability, cell proliferation, and autophagy, while promoting the apoptosis of MM cells in vitro and MM xenograft in vivo.
Molecular mechanism: hsa_circ_0003489/hsa-miR-874-3p/HDAC1 axis
Survival: -
Supported No.:
 2
Description:

The hsa_circ_0003489/miR-874-3p/HDAC1 axis critically regulates the balance between apoptosis and autophagy. Silencing hsa_circ_0003489 sensitizes MM cells to BTZ by inhibiting autophagy and thus may boost the therapeutic effects of BTZ.
Other information
Title:

Inhibition of hsa_circ_0003489 shifts balance from autophagy to apoptosis and sensitizes multiple myeloma cells to bortezomib via miR-874-3p/HDAC1 axis.

Journal: J Gene Med
Published: 2021/2/25
PubMed ID: 33625798