circRNA basic information
circBase ID: hsa_circ_0065149
Name: -
Synonym: circ_0065149
Host Gene: hsa-miR-330-5p
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human umbilical vein endothelial cells (HUVECs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-330-5p
Biological function: Overexpression of circ_0065149 promoted the cell viability and inhibited the apoptosis of ox-LDL-induced HUVECs. Overexpression of circ_0065149 also promoted the migration and invasion of ox-LDL-induced HUVECs.
Molecular mechanism: The expression of miR-330-5p was inhibited by overexpression of circ_0065149. Furthermore, circ_0065149 overexpression significantly inhibited the expressions of nuclear NF-¦ÊBp65 and suppressed the production of TNF-¦Á, IL-6, and IL-1beta in ox-LDL-induced HUVECs, which was rescued by the miR-330-5p mimic.
Survival: -
Supported No.:
 1
Description:

These findings suggest that circ_0065149 plays an important role in the proliferation, apoptosis, and inflammatory response of HUVECs via targeting miR-330-5p.
Other information
Title:

Circ_0065149 Alleviates Oxidized Low-Density Lipoprotein-Induced Apoptosis and Inflammation in Atherosclerosis by Targeting miR-330-5p.

Journal: Front Genet
Published: 2021/2/20
PubMed ID: 33603770