circRNA basic information
circBase ID: -
Name: hsa_circ_PIP5K1A
Synonym: circ_PIP5K1A
Host Gene: hsa-miR-101
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: 16HBE, A549, H1299
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ABCC1
Associated microRNA: hsa-miR-101
Biological function: Knockdown of exosomal circ_PIP5K1A inhibited NSCLC cell proliferation, migration, and invasion and promoted apoptosis and cisplatin sensitivity
Molecular mechanism: circ_PIP5K1A positively regulated ABCC1 expression by sponging hsa-miR-101
Survival: -
Supported No.:
 4
Description:

circ_PIP5K1A positively regulated ABCC1 expression by sponging miR-101. Exosomal circ_PIP5K1A knockdown inhibited NSCLC progression and promoted cisplatin sensitivity by regulating miR-101/ABCC1 axis, providing a novel avenue for treatment of NSCLC.
Other information
Title:

Exosomal circ_PIP5K1A regulates the progression of non-small cell lung cancer and cisplatin sensitivity by miR-101/ABCC1 axis.

Journal: Mol Cell Biochem
Published: 2021/2/12
PubMed ID: 33570734