circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA_000684
Host Gene: hsa-miR-145
 
 
 
Disease basic information
DO ID:
 3498
DO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HUVECs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: KLF5
Associated microRNA: hsa-miR-145
Biological function: CircRNA_000684 repression or miR-145 elevation inhibited the proliferation, invasion and migration of PDAC cells and HUVEC angiogenesis
Molecular mechanism: negatively regulated hsa-miR-145 expression, while hsa-miR-145 negatively regulated KLF5
Survival: -
Supported No.:
 1
Description:

CircRNA_000684 negatively regulated miR-145 expression, while miR-145 negatively regulated KLF5. In-vivo, circRNA_000684 elevation or miR-145 repression promoted tumor growth.
Other information
Title:

Repression of circRNA_000684 inhibits malignant phenotypes of pancreatic ductal adenocarcinoma cells via miR-145-mediated KLF5.

Journal: Pancreatology
Published: 2021/2/11
PubMed ID: 33563550