circRNA basic information
circBase ID: -
Name: hsa_circ_EHBP1
Synonym: -
Host Gene: hsa-miR-130a-3p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: UM-UC-3, T24, 5637
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: TGFbetaR1/VEGF-D signaling
Associated microRNA: hsa-miR-130a-3p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: poor
Supported No.:
 1
Description:

the circEHBP1/miR-130a-3p/TGFbetaR1/VEGF-D axis contributes to lymphangiogenesis and lymphatic metastasis of bladder cancer independent of VEGF-C, which might lead to the development of circEHBP1 as a potential biomarker and promising therapeutic target for lymphatic metastasis in bladder cancer.
Other information
Title:

circEHBP1 promotes lymphangiogenesis and lymphatic metastasis of bladder cancer via miR-130a-3p/TGFbetaR1/VEGF-D signaling.

Journal: Mol Ther
Published: 2021/2/6
PubMed ID: 33545359