circRNA basic information
circBase ID: -
Name: hsa_circ_AFF2
Synonym: circ_AFF2
Host Gene: hsa-miR-375
 
 
 
Disease basic information
DO ID:
 848
DO name: arthritis
Disease details: arthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: FLS-RA cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TAB2
Associated microRNA: hsa-miR-375
Biological function: Cell cycle, proliferation and inflammatory response were blocked while apoptosis was promoted in FLS-RA after the downregulation of circ_AFF2.
Molecular mechanism: circ_AFF2 promoted the expression of TAB2 by targeting miR-375.
Survival: -
Supported No.:
 1
Description:

These findings clarified that circ_AFF2 induced cell progression, inflammatory response in FLS-RA cells via the miR-375/TAB2 axis. Circ_AFF2 could be used as a biomarker in the diagnosis and treatment of RA.
Other information
Title:

Circ_AFF2 facilitates proliferation and inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis via the miR-375/TAB2 axis.

Journal: Exp Mol Pathol
Published: 2021/2/4
PubMed ID: 33535081