circRNA basic information
circBase ID: hsa_circ_0071127
Name: hsa_circ_NR3C2
Synonym: -
Host Gene: hsa-miR-513a-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: MCF-7, T-47D, BT474, MDA-MB-231, BT549, HEK293
circRNA-disease information
Detected method:
Q
S
M
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-513a-3p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: better
Supported No.:
 1
Description:

we elucidated a bona fide circNR3C2/miR-513a-3p/HRD1/Vimentin axis that negatively regulates the metastasis of TNBC, suggesting that circNR3C2 and HRD1 can act as potential prognostic biomarkers. Our study may facilitate the development of therapeutic agents targeting circNR3C2 and HRD1 for patients with aggressive breast cancer.
Other information
Title:

CircNR3C2 promotes HRD1-mediated tumor-suppressive effect via sponging miR-513a-3p in triple-negative breast cancer.

Journal: Mol Cancer
Published: 2021/2/4
PubMed ID: 33530981