circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: circ-ITCH
Host Gene: hsa-miR-199a-5p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HGC-27, AGS, MKN-45
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: Klotho
Associated microRNA: hsa-miR-199a-5p
Biological function: circ-ITCH overexpression inhibited the proliferation, migration, invasion and epithelial mesenchymal transition (EMT) of GC cells
Molecular mechanism: regulating hsa-miR-199a-5p/Klotho axis
Survival: -
Supported No.:
 3
Description:

circ-ITCH suppresses metastasis of GC by acting as the sponge of miR-199a-5p and increasing Klotho expression, which serves as a potential biomarker and targets for the diagnosis and therapy of GC.
Other information
Title:

Circular RNA ITCH suppresses metastasis of gastric cancer via regulating miR-199a-5p/Klotho axis.

Journal: Cell Cycle
Published: 2021/1/28
PubMed ID: 33499704