circRNA basic information
circBase ID: -
Name: mmu_circ_USP1
Synonym: -
Host Gene: mmu-miR-194-5p
 
 
 
Disease basic information
DO ID:
 557
DO name: kidney disease
Disease details: kidney injury
Species: mouse
Species details: mouse
Sample type: tissue, cell line
Sample type details: HK_2
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: DNMT3A
Associated microRNA: mmu-miR-194-5p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

silencing circ-USP1 reduced DNMT3A expression in the kidney of mice that received renal allografts. Circ-USP1 functions as a competing endogenous RNA for miR-194-5p. This occurs in order to regulate DNMT3A expression in kidney injury induced by hypoxia in acute renal allografts.
Other information
Title:

Silencing circ-USP1 protects the renal tubular from kidney injury induced by hypoxia via modulating miR-194-5p/DNMT3A axis in acute renal allografts.

Journal: J Cell Mol Med
Published: 2021/1/24
PubMed ID: 33484504