circRNA basic information
circBase ID: -
Name: hsa_circ_RUNX1
Synonym: -
Host Gene: hsa-miR-296-3p
 
 
 
Disease basic information
DO ID:
 3969
DO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human thyroid follicular epithelial cell line (Nthy-ori 3-1), human PTC cell lines (KTC-1, B-CPAP, TPC-1, K1, IHH-4, HEK-293T)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: DDHD2
Associated microRNA: hsa-miR-296-3p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: poor
Supported No.:
 1
Description:

The strong antitumor effect of miR-296-3p and the tumor-promoting effect of DDHD2 were further investigated in PTC, indicating that circRUNX1 modulates PTC progression through the miR-296-3p/DDHD2 pathway. Overall, circRUNX1 plays an oncogenic role in PTC and provides a potentially effective therapeutic strategy for PTC progression.
Other information
Title:

Circular RNA circRUNX1 promotes papillary thyroid cancer progression and metastasis by sponging MiR-296-3p and regulating DDHD2 expression.

Journal: Cell Death Dis
Published: 2021/1/23
PubMed ID: 33479208