circRNA basic information
circBase ID: hsa_circ_0000554
Name: hsa_circ_LIN52
Synonym: -
Host Gene: hsa-miR-485-5p
 
 
 
Disease basic information
DO ID:
 5041
DO name: esophageal cancer
Disease details: esophageal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: KYSE-150, Eca109, TE-1, TE-10
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: FERMT1
Associated microRNA: hsa-miR-485-5p
Biological function: Both circ_0000554 and FERMT1 repression blocked cell colony formation, migration, invasion and elevated cell radiosensitivity and apoptosis in esophageal cancer cells
Molecular mechanism: circ_0000554 served as a sponge for hsa-miR-485-5p in esophageal cancer cells
Survival: -
Supported No.:
 1
Description:

FERMT1 enhancement reversed circ_0000554 inhibition-mediated effects on the colony formation, migration, invasion, radiosensitivity and apoptosis of esophageal cancer cells. Circ_0000554 silencing repressed EC progression and enhanced cell radiosensitivity through downregulating FERMT1 via sponging miR-485-5p, which provided a possible method for improving the radioresistence of esophageal cancer.
Other information
Title:

Circular RNA hsa_circ_0000554 promotes progression and elevates radioresistance through the miR-485-5p/fermitin family members 1 axis in esophageal cancer.

Journal: Anticancer Drugs
Published: 2021/1/21
PubMed ID: 33470617