circRNA basic information
circBase ID: -
Name: hsa_circ_SDHC
Synonym: -
Host Gene: hsa-miR-127-3p
 
 
 
Disease basic information
DO ID:
 4451
DO name: renal carcinoma
Disease details: renal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: A498, 786-O, 769P, Caki-1
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CDKN3/E2F1
Associated microRNA: hsa-miR-127-3p
Biological function: circSDHC promoted tumor cell proliferation and invasion, both in vivo and in vitro
Molecular mechanism: circSDHC/hsa-miR-127-3p/CDKN3/E2F1 axis
Survival: -
Supported No.:
 1
Description:

Our data indicates, for the first time, an essential role for the circSDHC/miR-127-3p/CDKN3/E2F1 axis in RCC progression. Thus, circSDHC has potential to be a new therapeutic target in patients with RCC.
Other information
Title:

Circular RNA circSDHC serves as a sponge for miR-127-3p to promote the proliferation and metastasis of renal cell carcinoma via the CDKN3/E2F1 axis.

Journal: Mol Cancer
Published: 2021/1/21
PubMed ID: 33468140