circRNA basic information
circBase ID: -
Name: hsa_circ_SMAD4
Synonym: -
Host Gene: hsa-miR-1276
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: SGC_7901, MKN45, MGC_803, AGS, BGC_823
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: CTNNB1
Associated microRNA: hsa-miR-1276
Biological function: Circ_SMAD4 depletion impeded GC cell growth in vitro and restrained tumorigenesis in vivo
Molecular mechanism: nuclear circ_SMAD4 recruited TCF4 to facilitate CTNNB1 transcription, while cytoplasmic circ_SMAD4 sequestered hsa-miR-1276 to prevent the silence of CTNNB1 mRNA, leading to activation of Wnt/beta-catenin pathway
Survival: -
Supported No.:
 1
Description:

Circ_SMAD4 facilitated GC tumorigenesis by activating CTNNB1-dependent Wnt/beta-catenin pathway. Hopefully, the findings could provide new clues for improving GC prognosis and treatment.
Other information
Title:

Circ_SMAD4 promotes gastric carcinogenesis by activating wnt/beta-catenin pathway.

Journal: Cell Prolif
Published: 2021/1/19
PubMed ID: 33458917