circRNA basic information
circBase ID: hsa_circ_0004104
Name: hsa_circ_SPARC
Synonym: -
Host Gene: hsa-miR-539-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HGC-27, AGS
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: RNF2
Associated microRNA: hsa-miR-539-3p
Biological function: Circ_0004104 was upregulated in GC, and its knockdown repressed the proliferation, metastasis, and glutaminolysis of GC cells in vitro and reduced GC tumor growth in vivo
Molecular mechanism: regulating the hsa-miR-539-3p/RNF2 axis
Survival: -
Supported No.:
 1
Description:

Circ_0004104 accelerated GC progression via regulating the miR-539-3p/RNF2 axis, indicating that circ_0004104 might be a potential therapeutic target for GC.
Other information
Title:

Circ_0004104 Accelerates the Progression of Gastric Cancer by Regulating the miR-539-3p/RNF2 Axis.

Journal: Dig Dis Sci
Published: 2021/1/16
PubMed ID: 33449226