circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: -
Host Gene: hsa-miR-152-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human GC cells lines (AGS, HGC-27), human gastric mucosal epithelial cells (GES-1), DDP-resistant GC cells (AGS/DDP, HGC-27/DDP)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-152-3p
Biological function: Both circPVT1 and HDGF inhibition elevated cell sensitivity to DDP, suppressed cell viability, proliferation, and induced cell apoptosis in DDP-resistant GC cells.
Molecular mechanism: regulated the HDGF/PI3K/AKT pathway through sponging hsa-miR-152-3p
Survival: -
Supported No.:
 6
Description:

CircPVT1 regulated the chemoresistance and malignancy of GC through modulating HDGF expression via sponging miR-152-3p, providing a theoretical basis for the development of effective therapeutic strategies for GC.
Other information
Title:

Knockdown of cir_RNA PVT1 Elevates Gastric Cancer Cisplatin Sensitivity via Sponging miR-152-3p.

Journal: J Surg Res
Published: 2021/1/15
PubMed ID: 33444948