circRNA basic information
circBase ID: hsa_circ_0032434
Name: hsa_circ_PCNX
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: HeLa
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: p21
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

we propose that the interaction of circPCNX with AUF1 selectively prevents AUF1 binding to p21 mRNA, leading to enhanced p21 mRNA stability and p21 protein production, thereby suppressing cell growth.
Other information
Title:

AUF1 ligand circPCNX reduces cell proliferation by competing with p21 mRNA to increase p21 production.

Journal: Nucleic Acids Res
Published: 2021/1/15
PubMed ID: 33444453