circRNA basic information
circBase ID: -
Name: hsa_circ_NDUFB2
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: A549, H1299, HCC827, H1975, H1703, H460, H1650
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: IGF2BP
Associated microRNA: -
Biological function: inhibits growth and metastasis of NSCLC cells
Molecular mechanism: participates in the degradation of IGF2BPs and activation of anti-tumor immunity
Survival: -
Supported No.:
 1
Description:

circNDUFB2 participates in the degradation of IGF2BPs and activation of anti-tumor immunity during NSCLC progression via the modulation of both protein ubiquitination and degradation, as well as cellular immune responses.
Other information
Title:

circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity.

Journal: Nat Commun
Published: 2021/1/14
PubMed ID: 33436560