circRNA basic information
circBase ID: -
Name: -
Synonym: CircRNA_25487
Host Gene: hsa-miR-134-3p
 
 
 
Disease basic information
DO ID:
 10159
DO name: osteonecrosis
Disease details: trauma-induced osteonecrosis of femoral head
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: BMSCs
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: p21
Associated microRNA: hsa-miR-134-3p
Biological function: CircRNA_25487 suppression and miR-134-3p overexpression could promote cell proliferation and invasion while inhibited apoptosis of BMSCs and OLCs
Molecular mechanism: sponging hsa-miR-134-3p to upregulate the expression of p21
Survival: -
Supported No.:
 1
Description:

CircRNA_25487 suppression and miR-134-3p overexpression could promote cell proliferation and invasion while inhibited apoptosis of BMSCs and OLCs. miR-134-3p could target p21. CircRNA_25487 inhibited bone repair in TIONFH by sponging miR-134-3p to upregulate the expression of p21.
Other information
Title:

CircRNA_25487 inhibits bone repair in trauma-induced osteonecrosis of femoral head by sponging miR-134-3p through p21.

Journal: Regen Ther
Published: 2021/1/12
PubMed ID: 33426239