circRNA basic information
circBase ID: -
Name: hsa_circ_RSU1
Synonym: circRSU1
Host Gene: hsa-miR-93-5p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: Osteoarthritis
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: primary human articular chondrocytes (HCs)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: MAP3K8
Associated microRNA: hsa-miR-93-5p
Biological function: circRSU1 was induced by IL-1beta and H2O2_timulation, and it subsequently regulated oxidative stress-triggered inflammation and extracellular matrix (ECM) maintenance in HCs, by modulating the MEK/ERK1/2 and NF-¦ĘB cascades.
Molecular mechanism: Ectopic expression of circRSU1 in mouse joints promoted the production of ROS and loss of ECM, which was rescued by mutation of the mir-93-5p target sequence in circRSU1
Survival: -
Supported No.:
 1
Description:

We identified a circRSU1-miR-93-5p-MAP3K8 axis that modulates the progression of OA via oxidative stress regulation, which could serve as a potential target for OA therapy.
Other information
Title:

Novel role of circRSU1 in the progression of osteoarthritis by adjusting oxidative stress.

Journal: Theranostics
Published: 2021/1/8
PubMed ID: 33408787