circRNA basic information
circBase ID: hsa_circ_0114876
Name: -
Synonym: circ_0114876
Host Gene: hsa-miR-671
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: Osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: CHON-001 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TRAF2
Associated microRNA: hsa-miR-671
Biological function: inhibition of circ_0114876 could induce cell viability and suppress inflammation as well as inhibit cell apoptosis in IL-1beta induced CHON-001 cells.
Molecular mechanism: Circ_0114876 regulated TRAF2 expression via sponging miR-671 in CHON-001 cells.
Survival: -
Supported No.:
 2
Description:

Circ_0114876 targeted miR-671 to regulate cell progression and inflammation via modulating TRAF2 expression in IL-1beta induced CHON-001 cells, and played an important regulatory mechanism in IL-1beta-induced chondrocyte injury, providing a novel diagnostics and therapeutics in OA.
Other information
Title:

Circ_0114876 promoted IL-1beta-induced chondrocyte injury by targeting miR-671/TRAF2 axis.

Journal: Biotechnol Lett
Published: 2021/1/7
PubMed ID: 33404903