circRNA basic information
circBase ID: -
Name: hsa_circ_NOL10
Synonym: -
Host Gene: hsa-miR-767-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: MCF-7, MDA-MB-231, MDA-MB-468, SKBR-3, BT-549, BT-474
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: SOCS2/JAK/STAT signaling
Associated microRNA: hsa-miR-767-5p
Biological function: suppress cell proliferation and metastasis
Molecular mechanism: sponging hsa-miR-767-5p to regulate SOCS2/JAK/STAT signaling
Survival: better
Supported No.:
 4
Description:

CircNOL10 repressed BC development via inactivation of JAK2/STAT5 signaling by regulating miR-767-5p/SOCS2 axis. Our findings offer the possibility of exploiting circNOL10 as a therapeutic and prognostic target for BC patients.
Other information
Title:

CircNOL10 suppresses breast cancer progression by sponging miR-767-5p to regulate SOCS2/JAK/STAT signaling.

Journal: J Biomed Sci
Published: 2021/1/6
PubMed ID: 33397365