circRNA basic information
circBase ID: hsa_circ_0045714
Name: -
Synonym: circ_0045714
Host Gene: hsa-miR-218-5p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: cell line
Sample type details: chondrocytes
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: HRAS
Associated microRNA: hsa-miR-218-5p
Biological function: ectopic overexpression of circ_0045714 abolished TNF-¦Á-induced cell apoptosis, inflammation, extracellular matrix (ECM) degradation promotion and proliferation inhibition.
Molecular mechanism: circ_0045714 targeted miR-218-5p, and miR-218-5p overexpression reversed the effects of circ_0045714 on TNF-¦Á-induced chondrocytes.
Survival: -
Supported No.:
 4
Description:

Up-regulation of circ_0045714 suppressed TNF-¦Á-induced chondrocyte growth inhibition, inflammation, and ECM degradation via miR-218-5p/HRAS axis, suggesting a novel insight into the pathogenesis of OA and the potential protective role of circ_0045714 in the occurrence and development of OA.
Other information
Title:

Circ_0045714 alleviates TNF-alpha-induced chondrocyte injury and extracellular matrix degradation through miR-218-5p/HRAS axis.

Journal: J Bioenerg Biomembr
Published: 2021/1/5
PubMed ID: 33394311