circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: cir-ITCH, circ-ITCH
Host Gene: hsa-miR-17-5p
 
 
 
Disease basic information
DO ID:
 1287
DO name: cardiovascular system disease
Disease details: cardiovascular disease
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-17-5p
Biological function: suppressing apoptosis
Molecular mechanism: inhibiting Wnt nad beta-Catenin Pathway
Survival: -
Supported No.:
 1
Description:

Circ-ITCH could protect myocardial cells from injuries caused by H2O2 by suppressing apoptosis while miR-17-5p played a reverse role.
Other information
Title:

Circular RNA ITCH mediates H(2)O(2)-induced myocardial cell apoptosis by targeting miR-17-5p via wnt/beta-catenin signalling pathway.

Journal: Int J Exp Pathol
Published: 2020/12/23
PubMed ID: 33350543