circRNA basic information
circBase ID: -
Name: hsa_circ_TADA2A
Synonym: circTADA2A
Host Gene: hsa-miR-129-5p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: Osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: MG63 and U2OS cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TRPS1 and YAP1
Associated microRNA: hsa-miR-129-5p
Biological function: circTADA2A knockdown inhibited cell proliferation and reduced DDP resistance
Molecular mechanism: MiR-129-5p was increased but TRPS1 and YAP1 were decreased by circTADA2A knockdown
Survival: -
Supported No.:
 2
Description:

CircRNA TADA2A could target miR-129-5p, which was competitively bound by TRPS1 and YAP1, thereby regulating OS cell proliferation and drug resistance
Other information
Title:

TRPS1 and YAP1 Regulate Cell Proliferation and Drug Resistance of Osteosarcoma via Competitively Binding to the Target of circTADA2A - miR-129-5p.

Journal: Onco Targets Ther
Published: 2020/12/10
PubMed ID: 33293831