circRNA basic information
circBase ID: -
Name: hsa_circ_PARD3
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 2876
DO name: laryngeal squamous cell carcinoma
Disease details: laryngeal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Tu 177, HOK, HEK293T, FD-LSC-1
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: PRKCI-Akt-mTOR pathway
Associated microRNA: -
Biological function: drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma
Molecular mechanism: inhibiting autophagy through the PRKCI-Akt-mTOR pathway
Survival: -
Supported No.:
 1
Description:

Our study reveals that the novel autophagy-suppressive circPARD3 promotes LSCC progression and chemoresistance through the PRKCI-Akt-mTOR pathway, providing new insights into circRNA-mediated autophagy regulation and potential biomarker and target for LSCC treatment.
Other information
Title:

circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway.

Journal: Mol Cancer
Published: 2020/11/26
PubMed ID: 33234130