circRNA basic information
circBase ID: -
Name: mmu_circ_SHOC2
Synonym: -
Host Gene: mmu-miR-7670-3p
 
 
 
Disease basic information
DO ID:
 6713
DO name: cerebrovascular disease
Disease details: ischemic stroke
Species: mouse
Species details: mouse
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SIRT1
Associated microRNA: mmu-miR-7670-3p
Biological function: suppressed neuronal apoptosis and ameliorated neuronal damage
Molecular mechanism: via the mmu-miR-7670-3p/SIRT1 Axis
Survival: -
Supported No.:
 1
Description:

our findings indicate that circSHOC2 in IPAS-EXOs suppressed neuronal apoptosis and ameliorated neuronal damage by regulating autophagy and acting on the miR-7670-3p/SIRT1 axis, which might contribute to a therapeutic strategy for ischemic stroke treatment.
Other information
Title:

Exosome-Shuttled circSHOC2 from IPASs Regulates Neuronal Autophagy and Ameliorates Ischemic Brain Injury via the miR-7670-3p/SIRT1 Axis.

Journal: Mol Ther Nucleic Acids
Published: 2020/11/25
PubMed ID: 33230464