circRNA basic information
circBase ID: -
Name: hsa_circ_ERBIN
Synonym: -
Host Gene: hsa-miR-125a-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCT116, SW480, RKO, LoVo, DLD-1, HT-29, HEK293
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-125a-5p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

Our findings uncover a key mechanism for circ-Erbin mediated HIF-1alpha activation by miR-125a-5p-5p/miR-138-5p/4EBP-1 axis and circ-ERBIN is a potential target for CRC treatment.
Other information
Title:

The circular RNA circ-ERBIN promotes growth and metastasis of colorectal cancer by miR-125a-5p and miR-138-5p/4EBP-1 mediated cap-independent HIF-1alpha translation.

Journal: Mol Cancer
Published: 2020/11/24
PubMed ID: 33225938