circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: -
Host Gene: hsa-miR-29a-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: MDA-MB-231, MCF7
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: AGR2-HIF-1alpha Pathway
Associated microRNA: hsa-miR-29a-3p
Biological function: Inhibition of circPVT1 or overexpression of miR-29a-3p remarkably suppressed BC cell proliferation, invasion and migration while promoted cell apoptosis
Molecular mechanism: promoted AGR2 and HIF-1alpha expression by repressing hsa-miR-29a-3p
Survival: -
Supported No.:
 4
Description:

CircPVT1 acts as an oncogene in BC via promoting the growth, invasion, migration and inhibiting apoptosis through miR-29a-3p-mediated AGR2-HIF-1alpha axis.
Other information
Title:

CircPVT1 Promoted the Progression of Breast Cancer by Regulating MiR-29a-3p-Mediated AGR2-HIF-1alpha Pathway.

Journal: Cancer Manag Res
Published: 2020/11/24
PubMed ID: 33223849