circRNA basic information
circBase ID: hsa_circ_0008305
Name: -
Synonym: circ_0008305
Host Gene: hsa-miR-186
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: SK-HEP-1, Huh-7, Hep-3B, HepG2, SMMCC7721, LO2
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TMED2
Associated microRNA: hsa-miR-186
Biological function: aggravates hepatocellular carcinoma growth
Molecular mechanism: binding to hsa-miR-186 and inducing TMED2
Survival: -
Supported No.:
 1
Description:

circ_0008305 up-regulated TMED2 expression by sponging miR-186, which resulted in significantly induced HCC progression in vitro and in vivo. These revealed the significant role of circ_0008305 in HCC progression, which might indicate a new perspective on circRNAs in HCC development.
Other information
Title:

Circular RNA circ_0008305 aggravates hepatocellular carcinoma growth through binding to miR-186 and inducing TMED2.

Journal: J Cell Mol Med
Published: 2020/11/20
PubMed ID: 33210454